Any macOS from 10.11 El Capitan through the latest macOS 15 Sequoia is not officially supported. The Best Workaround: Using a MIDI-to-USB Interface
The is a legacy MIDI controller that presents significant challenges for modern Mac users because it is not class-compliant . Unlike newer models, it requires specific drivers that M-Audio has long since stopped updating. Driver & Compatibility Overview m-audio radium 49 driver mac