| Drug Class | Example | Use Case | Vet Consideration | | :--- | :--- | :--- | :--- | | SSRIs | Fluoxetine (Reconcile®) | Canine separation anxiety, compulsive disorders | 4-6 wk onset; cannot stop abruptly | | SARI | Trazodone | Situational anxiety (fireworks, vet visit) | Short-acting; can cause dysphoria in some | | TCA | Clomipramine (Clomicalm®) | Separation anxiety, OCD | Anticholinergic side effects | | α-2 agonist | Dexmedetomidine (Sileo®) | Noise aversion (dogs) | Oromucosal gel; do not use with NSAIDs | | NMDA antagonist | Memantine + Fluoxetine | Canine compulsive disorder (refractory) | Off-label; requires specialist |